Volume 8, Issue 5, October 2020, Page: 84-91
Prevalence and Biomarkers of Diabetic Kidney Disease in Diabetic Patients on Treatment in Buea and Ngaoundere, Cameroon
Mbarawa Marat Kofia Ibrahim, Department of Medical Laboratory Sciences, Faculty of Health Sciences, University of Buea, Buea, Cameroon; Medical Research and Applied Biochemistry Laboratory, Faculty of Health Sciences, University of Buea, Buea, Cameroon
Asongalem Emmanuel Acha, Department of Biomedical Sciences, Faculty of Health Sciences, University of Buea, Buea, Cameroon
Nsagha Dickson Shey, Department of Public Health and Hygiene, Faculty of Health Sciences, University of Buea, Buea, Cameroon
Njouendou Abdel Jelil, Medical Research and Applied Biochemistry Laboratory, Faculty of Health Sciences, University of Buea, Buea, Cameroon; Department of Biomedical Sciences, Faculty of Health Sciences, University of Buea, Buea, Cameroon
Assob Nguedia Jules Clement, Medical Research and Applied Biochemistry Laboratory, Faculty of Health Sciences, University of Buea, Buea, Cameroon; Department of Biomedical Sciences, Faculty of Health Sciences, University of Buea, Buea, Cameroon
Received: Jul. 23, 2020;       Accepted: Aug. 4, 2020;       Published: Oct. 30, 2020
DOI: 10.11648/j.bio.20200805.11      View  51      Downloads  26
Abstract
Diabetic Kidney Disease (DKD) is a complication of diabetes that often leads to the End Stage Renal Disease. It is characterised by the presence of persistent albuminuria and a reduction of the Glomerular Filtration Rate (GFR) in diabetic condition. No study has revealed the prevalence of DKD in Cameroon. This cross-sectional study was conducted in Buea and Ngaoundere to determine the prevalence of DKD and characterize its biochemical profile in diabetic population under medical care. A total of 250 diabetics were enrolled with a mean age of 56.78±12.06 years, out of which 59.6% were diagnosed with Chronic Kidney Disease (CKD), 32.8% presented micro-albuminuria and 3.6% were diagnosed with macroalbuminuria. The prevalence of DKD was 15.2% out of which 78.9% were females (p=0.002). The prevalence of the co-morbidity hypertension and DKD was 8.8%. Significant association was found between DKD and two variables: female gender (OR: 2.28 (1.21-4.29); p=0.002) and hyper-creatinemia (OR: 3.47 (2.13-5.66); p < 0.001). The high prevalence of micro-albuminuria found in this study may reflect a high frequency of micro-albuminuria in diabetic population in Cameroon. This study is the first, to assess DKD in Cameroon according to the ADA consensus on CKD and diabetes. The findings showed that, diabetic complication is a serious problem in Cameroon and, more actions should be taken to improve its management.
Keywords
DKD, Diabetes, Cameroon, GFR, ADA Consensus, KDIGO
To cite this article
Mbarawa Marat Kofia Ibrahim, Asongalem Emmanuel Acha, Nsagha Dickson Shey, Njouendou Abdel Jelil, Assob Nguedia Jules Clement, Prevalence and Biomarkers of Diabetic Kidney Disease in Diabetic Patients on Treatment in Buea and Ngaoundere, Cameroon, American Journal of Bioscience and Bioengineering. Vol. 8, No. 5, 2020, pp. 84-91. doi: 10.11648/j.bio.20200805.11
Copyright
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Reference
[1]
O. Gheith, N. Farouk, N. Nampoory, M.. Halim and T. Al-Otaibi, “Diabetic kidney disease: worldwide difference of prevalence and risk factors,” Journal of Nephropharmacology, vol. 5, no. 1, pp. 49-56, 2016.
[2]
Y. C. Lin, Chang, S. Y. Yang, K. D. u and T. S. Chu, “Update of pathophysiology and management of diabetic kidney disease,” Journal of Formos and Medical Association, vol. 117, pp. 662-675, 2018.
[3]
P. Fioretto, M. L. Caramori, M. Mauer, “The kidney in diabetes: Dynamic pathways of injury and repair. The Camillo Golgi Lecture 2007,” Diabetologia, vol. 51, pp. 1347-1355, 2008.
[4]
H. J. Anders, T. B. Nuber, B. Isermann and M. Schiffer, “CKD in diabetes: Diabetic kidney disease versus nondiabetic kidney disease,” Nature Revue of Nephrology, vol. 14, pp. 361-377, 2018.
[5]
K. R. Tuttle, G. L. Bakris, R. W. Bilous, J. L. Chiang, I. H. de Boer, J. Goldstein-Fuchs, I. B. Hirsch, K. Kalantar-Zadeh, A. S. Narva, S. D. Navaneethan, J. J. Neumiller, U. D. Patel, R. E. Ratner, A. T. Whaley-Connell and M. E. Molitch, “Diabetic Kidney Disease: A Report from an ADA Consensus Conference,” Diabetes Care, vol. 37, pp. 2864-2883, 2014.
[6]
I. H. de Boer, T. C. Rue, Y. N. Hall, P. J. Heagerty, N. S. Weiss, J. Himmelfarb, Temporal trends in the prevalence of diabetic kidney disease in the United States. Journal of American Medical Association, vol. 305, pp. 2532-2539, 2011.
[7]
K. Al-Rubeaan, A. M. Youssef, S. N. Subhani, N. A. Ahmad, A. H. Al-Sharqawi, H. M. Al-Mutlaq, K. D. Satish, D. Al-Naqeb, “Diabetic Nephropathy and Its Risk Factors in a Society with a Type 2 Diabetes Epidemic: A Saudi National Diabetes Registry-Based Study,” PLoS ONE, vol. 9, no. 2, pp. e88956, 2014.
[8]
W. H. Herman, R. E. Aubert, M. M. Engelgau, T. J. Thompson, M. A. Ali, E. S. Sous, M. Hegazy, A. Badran, S. J. Kenny, E. W. Gunter, A. M. Malarcher, R. J. Brechner, S. F. Wetterhall, F. DeStefano, P. J. Smith, M. Habib, S. Abd El Shakour, A. S. Ibrahim, E. M. El Behairy, “Diabetes Mellitus in Egypt: Diabetes Mellitus in Egypt: glycaemic control and microvascular and neuropathic complications,” Diabetes Medicine, vol. 15, no. 12, pp. 1045-1051, 1998.
[9]
A. S. Levey, P. E. de Jong, J. Coresh, M. El Nahas, B. C. Astor, K. Matsushita, R. T. Gansevoort, B. L. Kasiske and K. U. Eckardt, “The definition, classification, and prognosis of chronic kidney disease: a KDIGO Controversies Conference report,” Kidney International, vol. 80, pp. 17-28, 2011.
[10]
National Kidney Foundation, “KDOQI Clinical Practice Guideline for Diabetes and CKD: 2012 update,” American Journal of Kidney Disease, vol. 60, no. 5, pp. 850-886, 2012.
[11]
V. M. Muthuppalaniappan and M. M. Yaqoob. “Ethnic/Race Diversity and Diabetic Kidney Disease,” Journal of Clinical Medicine. Vol. 4, pp. 1561-1565, 2015.
[12]
K. A. Earl, K. K. Porter, J. Ostberg and J. S. Yudkin, “Variation in the progression of diabetic nephropathy according to racial origin,” Nephrology and Dialysis Transplantation, vol. 16. Pp. 286-290, 2001.
[13]
Centers for Disease Control and Prevention (CDC), “Report CMaMW. Prevalence of overweight and obesity among adults with diagnosed diabetes—United States, 1988-1994 and 1999-2002,” MMWR Morbidity and Mortality Wkly Report, vol. 53, no. 45, pp. 1066-1068, 2004.
[14]
Centers for Disease Control and Prevention. “National Diabetes Statistics Report, 2017. Atlanta, GA: Centers for Disease Control and Prevention,” U. S. Department of Health and Human Services; 2017.
[15]
D. Worku, L. Hamza and K. Woldemichael “Patterns of Diabetic Complications at Jimma University Specialized Hospital, Southwest Ethiopia”. Ethiopian Journal of Health Science, vol. 20, no. 1, pp. 33-39, 2010.
[16]
C. Bouzid, H. Smida, A. Kacem, Z. Turki, L. B. Salem, C. B. Rayana and C. B. Slama, “Kidney Failure in Tunisian Type 2 Diabetes Patients Hospitalized: Frequency and Associated Factors,” La tunisie Medicale, vol. 89, no. 01, pp. 10-15, 2011.
[17]
M. N. Janmohamed, S. E. Kalluvya, A. Mueller, R. Kabangila, L. R. Smart, J. A. Downs, et al., “Prevalence of chronic kidney disease in diabetic adult out-patients in Tanzania,” BMC Nephrology, vol. 14, pp. 183-187, 2013.
[18]
B. C. T. Mpondo, E. Neilson, A. Ernest, “Prevalence of chronic kidney disease in diabetic adult out-patients in Tanzania,” BMC Nephrology, vol. 17, pp. 71-72, 2016.
[19]
M. A. Sobh, F. E. Moustafa, R. M. Ramzy, A. M. Deelder, M. A. Ghoneim, “Schistosoma haematobium-induced glomerular disease: an experimental study in the golden hamster,” Nephron, vol. 57, pp. 216-24, 1991.
[20]
W. L. C. dos-Santos, G. M. M. Sweet, M. Bahiense-Oliveira, P. N. Rocha, “Schistosomal glomerulopathy and changes in the distribution of histological patterns of glomerular diseases in Bahia, Brazil,” Mem Inst Oswaldo Cruz, vol. 106, pp. 901-904, 2011.
[21]
M. K. Yu, C. R. Lyles, L. A. Bent-Swah, B. A. Young and the Pathways authors, “Risk factor, age and sex differences in chronic kidney disease prevalence in a diabetic cohort: The Pathways Study,” American Journal of Nephrology, vol. 36, no. 3, pp. 245-251, 2012.
[22]
I. Laranjinhaa, P. Matiasa, S. Mateusb, F. Aguiarb, P. Pereirab, M. P. Santosb, R. Costab, A. Lourencob, J. Guiab, J. D. Barataa and B. L. Campos, “Diabetic kidney disease: Isthereanon-albuminuric phenotype in type 2 diabetic patients?” Nefrologia, vol. 36, no. 5, pp. 503-509, 2016.
[23]
A. Verma, S. Vyas, A. Agarwal, S. Abbas, D. P. Agarwal and R. Kumar, “Diabetic Kidney Disease and Hypertension: A True Love Story,” Journal of Clinical Diagnosis and Research, vol. 10, no. 3, pp. 11-13, 2016.
[24]
S. P. Choukem, A. Dzudi, M. Dehayem, M. P. Halle, M. S. Doualla, H. Luma and P. Kengne, “Comparison of different blood pressure indices for the prediction of prevalent diabetic nephropathy in a sub-Saharan African population with type 2 diabetes,” Pan-African Medical Journal, vol. 11, pp. 67-74, 2012.
[25]
V. Rigalleau, M. C. Beauvieux, C. Gonzalez, C. Raffaitin, C. Lasseur, C. Combe, P. Chaveau, R. De la Faille, C. Rigothier, N. Barthe and H. Gin, “Estimation of renal function in patients with diabetes,” Diabetes Metabolic, vol. 37, pp. 359-366, 2011.
[26]
D. D. Agoons, E. V. Balti, F. F. Kaze, M. Azabji-Kenfack, G. Ashungtantang, A. P. Kegne, E. Sobngwi and J. C. Mbanya, “Performance of three glomerular filtration rate estimation equations in a population of sub-Saharan Africans with Type 2 diabetes,” Diabetes Medical, vol. 33, no. 9, pp. 1291-1298, 2016.
[27]
M. K. I. Mbarawa, G. M. Ndoe, L. L. Mohamadou, T. T. Marcel, S. L. A. Kagoue and G. D. Fokam, “A Comparison of three Methods to Estimate the Glomerular Filtration Rate in Diabetic Patients at the Ngaoundere Regional Hospital (Cameroon),” International Journal of Health and Biological Science, vol. 2, no. 1 pp. 6-10, 2019.
[28]
E. Sobngwi, J. C. Mbanya, E. N. Moukouri and K. B. Ngu, “Microalbuminuria and retinopathy in a diabetic population of Cameroon,” Diabetes Research and Clinical Practice, vol. 44, no. 3, pp. 191-196, 1999.
[29]
M. E. A. Bissong, G. N. Teke, M. Sanje, H. Goneh, F. E. T. Foka and H. L. Kamga, “Microalbuminuria in Diabetic Patients in the Bamenda Health District,”. Scientific Journal of Clinical Medicine, vol. 6, no. 4, pp. 63-67, 2017.
[30]
S. C. Satchell and J. E. Tooke, “What is the mechanism of microalbuminuria in diabetes: a role for the glomerular endothelium?” Diabetologia, vol. 51, no. 5, pp. 714-725, 2008.
[31]
E. T. Efundem, J. C. N. Assob, V. F. Feteh and S. P. Choukem, “Prevalence and associations of microalbuminuria in proteinuria-negative patients with type 2 diabetes in two regional hospitals in Cameroon: a cross-sectional study,” BMC Research Notes, vol. 10, pp. 477-481, 2017.
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