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A Study of Biological Markers in HIV Disease Progression and Management in yhe Highly Active Antiretroviral Therapy (HAART) Era
Issue:
Volume 1, Issue 2, April 2013
Pages:
24-37
Abstract: Human Immunodeficiency Virus (HIV), the causative agent in AIDS has been a challenge to medical fraternity from the time since it was first discovered in 1983. About 40 million people are living with HIV infection globally and 99% of the infected people are in south East Asia (SEA). With inception of highly active antiretroviral therapy (HAART), the quality of life of HIV infected individuals is gradually improving. The number of people contracting new infections has been on decline globally and those having access to HAART are increasing. Close monitoring of HIV infected patients is essential in reducing the morbidity and mortality of HIV patients. Monitoring HIV disease progression, deciding the time to initiate HAART requires evaluation of TCD4+ cell counts and HIV/RNA viral load at regular intervals. Considering the fact that it is the resource restrained developing countries that carry most of the burden of HIV, studies recently have been carried out to evaluate the utility of low cost, easily performed alternate biomarkers that can be used for HIV disease management and response to HAART therapy. Very few studies are available that have demonstrated the role of alternate biomarkers to monitor HIV disease progression and assessing response to HAART.
Abstract: Human Immunodeficiency Virus (HIV), the causative agent in AIDS has been a challenge to medical fraternity from the time since it was first discovered in 1983. About 40 million people are living with HIV infection globally and 99% of the infected people are in south East Asia (SEA). With inception of highly active antiretroviral therapy (HAART), th...
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The Possibility of Information Loss in Transcribing Genetic Sequence of DNA into Proteins due to Acceleration of Universe
Alireza Sepehri,
Somayyeh Shoorvazi
Issue:
Volume 1, Issue 2, April 2013
Pages:
38-42
Abstract: One of the most exciting subjects in science is the possibility of information loss in transcribing genetic se-quence of DNA into proteins due to acceleration of Universe. This research is the first attempt to investigate this subject. First, the probability that DNA is produced due to acceleration of Universe is obtained. It is found that as the Unruh tem-perature increases, the effect ofacceleration on the production of DNA becomes systematically more effective, because effect at higher temperatures, the energy that is supplied to keep Universe undergoing acceleration becomes more and consequently more DNAs are produced. Then the average number of binding proteins to DNA in two regions of Rindler space of Universe is calculated. The effect of proteins produced in region II doesn’t observe in accelerating Universe. One observer in acceleratingUniverse is unable to access information about the whole of space-time since, from his perspective, a communication horizon appears. This can result in a loss of information and a corresponding degradation ofprotein binding to DNA. This information loss disrupts the cellular dynamics and can lead to serious defects, including cancer.Next the averge number of extra base pairs that are produced in DNA structure by the acceleration of Universe is derived. These extra base pairs cause to be stored more information in DNA.These information can be transcribed of DNA into proteins and lead to dangerous activity in Human body.Finally,the probability for substituting AT pair by CG pair in DNA structure is calculated. It’s concluded that with increasing the Unruh temperature, more AT base pairs may be substituted by CG pairs and the probability for generating cancer due to this point mutation is increased.
Abstract: One of the most exciting subjects in science is the possibility of information loss in transcribing genetic se-quence of DNA into proteins due to acceleration of Universe. This research is the first attempt to investigate this subject. First, the probability that DNA is produced due to acceleration of Universe is obtained. It is found that as the U...
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Information Loss in Transcribing Genetic Sequence from DNA into Protein
Alireza Sepehri,
Somayyeh Shoorvazi
Issue:
Volume 1, Issue 2, April 2013
Pages:
31-35
Abstract: The main question is the probability of information loss in binding site of DNA due to interaction between DNA bead charges? Information loss in the gene expression disrupts the cellular dynamics and can lead to serious defects, including cancer. Using quantum biology ,a mechanism for calculating the amount of information loss in transcribing ge-netic sequence from DNA to protein is proposed. In this proposal, there are three different Hilbert spaces that belong to degrees of freedom of protein, binding site, and unbinding site of DNA. At first stage it is shown that the internal stationary state of the cell can be represented by a maximally entangled two-mode squeezed state of DNA and protein. At second stage,the state of the DNA is described by a maximally entangled two-mode squeezed state of DNA binding site and DNA unbinding site. Finally it is shown that the entanglement between protein and DNA is degraded due to interaction between DNA binding site and DNA unbinding site and consequently information is lost.
Abstract: The main question is the probability of information loss in binding site of DNA due to interaction between DNA bead charges? Information loss in the gene expression disrupts the cellular dynamics and can lead to serious defects, including cancer. Using quantum biology ,a mechanism for calculating the amount of information loss in transcribing ge-ne...
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