Research Article
Sub Chronic Toxicity Study of Aqueous Leaves Extract of Maytenus Gracilipes on Some Biochemical Parameters and Histopathology of Liver and Kidneys in Mice
Issue:
Volume 12, Issue 2, April 2024
Pages:
24-31
Received:
7 February 2024
Accepted:
27 February 2024
Published:
17 April 2024
Abstract: Introduction: Traditional medicine is an ancient medical practice that is still widely used in prevention and treatment of various health problems worldwide, including Ethiopia. M.gracilipes is one of medicinal plant in Ethiopia used for treatment of various ailments still is very common. This study evaluated the sub-chronic toxic effects of M. gracilipes aqueous leaves extract on biochemical parameters and histopathology of liver and kidneys. Methods: For sub-chronic toxicity study a total of 30 mice were used, three groups (I–III) of mice (10 animals each) were used. Group I served as control and received a vehicle while groups II and III daily administered with 700 and 2100 mg/kg extract respectively orally by using oral gavage for 90 days. At the end of the experiment, the mice were sacrificed by using diethyl ether; blood was collected for assessing biochemical parameters and histopathological evaluations on liver and kidneys were performed. Results: Sub chronic treatment of extract for 90 days, at 700 and 2100 mg/kg body weight did not induce any sign of illness and /or death and had no adverse effect on biochemical parameters and blood parameters. Liver and kidney sections also revealed normal architecture, except some pyknotic nuclei and focal mononuclear leukocytic infiltrations observed in some of the liver and kidney tissues at higher dose (2100mg/kg). Conclusion: The results of this sub chronic toxicity study showed that M. gracilipes aqueous leaves extract is safe at daily doses of 700 mg/kg body weight, even when taken for longer period. At higher doses, however, the extract may induce mild hepatorenal toxicity.
Abstract: Introduction: Traditional medicine is an ancient medical practice that is still widely used in prevention and treatment of various health problems worldwide, including Ethiopia. M.gracilipes is one of medicinal plant in Ethiopia used for treatment of various ailments still is very common. This study evaluated the sub-chronic toxic effects of M. gra...
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Research Article
Performance Evaluation and Adaptability Study of Fodder Beet (Beta vulgaris L.) Cultivars in Highlands of Bale Zone South East Ethiopia
Wubshet Tesfaye*,
Gemechis Lencho,
Teklu Wegi,
Aliyi Kedu
Issue:
Volume 12, Issue 2, April 2024
Pages:
32-39
Received:
26 February 2024
Accepted:
23 March 2024
Published:
17 April 2024
Abstract: Shortage animal feed interims of quality and quantity is the major bottle neck in livestock production through the year in Ethiopia particularly in the highlands of Bale Zone. A study was conducted at Sinana Agricultural Research Center (SARC), South East Ethiopia for three consecutive cropping season (2020/21, 2021/22 and 2022/23) in two locations (Sinana on station and Agarfa subsite) to evaluate the adaptability of four Cultivars of Fodder beet (namely Bircks, Kulumsa, Magnum and Robbos). Experimental plots were laid out in a randomized complete block design with three replications. All cultivars were performed well. However, there is significant variation among the Cultivars. The combined result over locations over years indicated that, Kulumsa cultivars gives the highest shoot fresh biomass yield (41.88 t ha-1), root fresh biomass yield (86.49 t ha-1) and shoot Dry biomass yield (4.52 t ha-1). The remaining cultivars have not statistically significant different. Based on the results of this study, it is concluded that the Fodder beet Kulumsa cultivars was found a promising in terms of grain and biomass yield, than others that could be demonstrated and popularized as an alternative feed resources under smallholder conditions in the study areas and with similar climatic and edaphic conditions.
Abstract: Shortage animal feed interims of quality and quantity is the major bottle neck in livestock production through the year in Ethiopia particularly in the highlands of Bale Zone. A study was conducted at Sinana Agricultural Research Center (SARC), South East Ethiopia for three consecutive cropping season (2020/21, 2021/22 and 2022/23) in two locations...
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Mekebeb Afework
